An old friend and former patient of Wilson’s experiences paralysis in his right arm. Wilson takes this case himself. House thinks his friend has cancer like before, however Wilson stays optimistic until the worst happens. Now he is forced to take radical decisions. Cuddy continues her search for real estate.

On the eve of Thanksgiving, House and the team take on the case of James Sidas (guest star Esteban Powell), an exceptionally brilliant physicist and author who traded his successful career for a job as a courier. For the ailing patient, intelligence is a miserable burden that has prompted depression and addiction, and this, coupled [...]

After House’s medical license is reinstated, he reclaims his role as Head of Diagnostics in time to treat Hank Hardwick (guest star Troy Garity), an adult film star admitted to Princeton Plainsboro for pulsating eye pain. Meanwhile, Cuddy is reminded that Princeton Plainsboro is not conducive to healthy personal relationships.

After a wild night out, a teenage girl (Anna Attanasio) is brought to Princeton Plainsboro with severely swollen appendages. The team must work to diagnose the young girl, who is less than honest about what happened the night she fell ill. As her condition worsens, she becomes unable to distinguish fact from fiction. Meanwhile, Cuddy, [...]