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[Effect of flavonoids from the seed and fruit residue of
Hippophae rhamnoides L. on glycometabolism in mice]
[Article in Chinese]
School of Life Science, Normal University of
East China, Shanghai 200062.
OBJECTIVE: To investigate the effect of
flavonoids from the seed residue and fruit residue of Hippophae
rhamnoides L. (FSH and FFH) on glycometabolism in mice. METHOD: The
healthy male mice were randomly divided into control group, three
FSH treatment groups and three FFH treatment groups. FSH(50, 100,
150 mg/kg) and FFH (50, 100, 150 mg/kg) were given
intragastorically(i.g.). At the same time, the mice of control
group were given physiological saline. The levels of serum glucose,
serum cholesterol were determined when it lasted 7 and 14 days.
After 16 days glyconeogenesis test was made and liver glycogen was
analyzed. RESULT: The levels of serum glucose, serum cholesterol
and serum triglyceride were significantly reduced by high dose FSH
and FFH. The glyconegenesis was also obviously inhibited by FSH and
FFH. CONCLUSION: FSH and FFH can decrease the levels of blood
glucose and lipid in normal mice, and the effect of FSH and FFH on
glycometabolism may be related to the control of
glyconeogenesis.
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