I am interested in the structure-function of the neurotrophin proteins and their tyrosine kinase receptors (TrkA, TrkB & TrkC). These proteins play central roles in development, cell survival and function. Additionally they are implicated in a variety of disease states including Alzheimer's, Parkinson's and Huntington's diseases, inflammatory and neuropathic pain and certain forms of cancer.

We have identified the NGF binding domain on the TrkA receptor and determined its structure by X-ray crystallography in collaboration with Professor Leo Brady (Biochemistry). We have also determined the structure of neurotrophin-4 bound to its receptor TrkB. Using the coordinates of these receptors we have screened virtual libraries of small molecule compounds. Initial studies have identified compounds which bind to the wildtyp

Additionally the soluble TrkA-NGF binding domain (REN 1820) is now undergoing pre-clinical development and has been shown to be highly effective in the treatment of inflammatory states, and may be useful in control of pancreatitis and prostate cancer