Visceral Endoderm RAI-1 Speech and Motor Delay
source: http://www.ihop-net.org/UniPub/iHOP/bng/95801.html
clipped by chiroted Oct 16, 2007
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These results are confirmed in the F9 teratocarcinoma cell line , a model for retinoic acid-induced visceral endoderm differentiation in which we demonstrate that ablation of retinoic acid-induced Dab2 expression levels, by stable siRNA silencing of Dab2 
, blocks visceral
endoderm
differentiation. [2005]Phenotypic comparison between patients with deletions and patients with RAI1 
mutations show that 21 of 30
SMS features are the result of
haploinsufficiency of RAI1
, whereas cardiac anomalies,
speech and motor delay,
hypotonia
, short
stature, and
hearing loss
are
associated with 17p11.2 deletions rather than RAI1
mutations
(P<.05). [2006]
Notes by chiroted:
Relationship between Metallothionein, visceral endoderm, and speech, motor dely, hypotonia, short statue, and hearing loss!!!