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Gene Metal Transporting, Ferroportin

source: http://www.dsi.univ-paris5.fr/genatlas/fiche.php?n=10212

clipped by chiroted Oct 16, 2007

- Balance Ear Hearing Iron

DNA Reprogramming

  • Symbol SLC40A1 last update : 24/06/2006
    HGNC name solute carrier family 40 (iron-regulated transporter), member 1
    HGNC id 10909
    Corresponding disease HFE4
    Location 2q32
    Synonym name
    • metal transporting protein 1
    • ferroportin 1
    • iron regulated transporter 1
    • solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3
    Synonym symbol(s) IREG1, FPN1, HFE4, MTP1, SLC11A3, MST079, MSTP079
    DNA RNA EXP/sub-loc PROTEIN PATHOLOGY
    DNA
    TYPE functioning gene
    STRUCTURE 20,18 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site  &nbspmetal/iron
    motif
    text structure iron responsive element in the 5'utr, controlinggene expression through the cytoplasmic iron regulatory protein system
    MAPPING cloned Y linked N status provisional
    mode fluorescence in situ hybridization (FISH)
    Physical map
    LEREPO4 2q32.2 likely ortholog of mouse immediate early response, erythropoietin 4 ITGAV 2q31-q32.1 integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) KIAA1946 2q32.2 KIAA1946 protein ZSWIM2 2q32.2 zinc finger, SWIM domain containing 2 LOC391467 2 similar to Inosine-5-monophosphate dehydrogenase 1 (IMP dehydrogenase 1) (IMPDH-I) (IMPD 1) CALCRL 2q31.3 calcitonin receptor-like TFPI 2q31-q32.1 tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) LOC344328 2q32.2 similar to heat shock 70kD protein binding protein; progesterone receptor-associated p48 protein; putative tumor suppressor ST13; Hsp70-interacting protein CED-6 2q32.3-q33 similar to heat shock 70kD protein binding protein; progesterone receptor-associated p48 protein; putative tumor suppressor ST13; Hsp70-interacting protein DIRC1 2q33 disrupted in renal carcinoma 1 COL3A1 2q32.2 collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant) COL5A2 2q24.3-q31 collagen, type V, alpha 2 LOC339781 2q32.3 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) FLJ12519 2q32.3 hypothetical protein FLJ12519 SLC40A1 2q32 solute carrier family 40 (iron-regulated transporter), member 1 NS3TP1 2p24.3-q21.3 HCV NS3-transactivated protein 1 FLJ25415 2q32.3 hypothetical protein FLJ25415 OSGEPL1 2q32 O-sialoglycoprotein endopeptidase-like 1 LOC51240 2q32.3 hypothetical protein LOC51240 PMS1 2q31.1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) LOC285011 2q32.3 similar to HNRPC protein GDF8 2q32.2 growth differentiation factor 8 MGC13057 2q32.3 hypothetical protein MGC13057 HIBCH 2q32.3 3-hydroxyisobutyryl-Coenzyme A hydrolase INPP1 2q32 inositol polyphosphate-1-phosphatase FLJ20160 2q32.3 FLJ20160 protein LOC391468 2 similar to Hypothetical protein KIAA0286 (HA6800) NAB1 2q32.3-q33 NGFI-A binding protein 1 (EGR1 binding protein 1) GLS 2q32-q34 glutaminase STAT1 2q32.2-q32.3 signal transducer and activator of transcription 1, 91kDa STAT4 2q32.2-q32.3 signal transducer and activator of transcription 4 MYO1B 2q12-q34 myosin IB FLJ22833 2q32.3 hypothetical protein FLJ22833 SDPR 2q32-q33 serum deprivation response (phosphatidylserine binding protein) HSP40 2q32.3 HSP40 pseudogene TMEFF2 2q32.3-q33 transmembrane protein with EGF-like and two follistatin-like domains 2
    RNA
    Size 3460 bp
    TRANSCRIPTS type messenger
    EXPRESSION / SUBCELLULAR LOCALIZATION
    EXPRESSION (based on citations) widely
       expressed in
    organ(s)
    System Organ 1 organ 2 organ 3 organ 4 level
    blood / hematopoietic spleen        
    Digestive intestine small intestine duodenum    
      liver       highly
    Endocrine parathyroid       highly
    Hearing/Equilibrium ear       highly
    Urinary kidney        
    tissue
    System Tissue S_Tissue Ss_Tissue level
    Lymphoid        
    Muscular striatum skeletal   highly
    cells
    System Cell
    Blood/Hematopoietic kupffer
    Digestive enterocyte
    Lymphoid/Immune macrophage
    cell lineage
 

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